M143-0765 Screening compound: N-[4-chloro-2-(trifluoromethyl)phenyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide

M143-0765 Screening compound: N-[4-chloro-2-(trifluoromethyl)phenyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide
M143-0765 Screening compound: N-[4-chloro-2-(trifluoromethyl)phenyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound M143-0765
N-[4-chloro-2-(trifluoromethyl)phenyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M143-0765

Molecular Formula

C22H15ClF3N5OS (C22 H15 ClF3 N5 OS)

Compound Name

N-[4-chloro-2-(trifluoromethyl)phenyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide

IUPAC name

N-[4-chloro-2-(trifluoromethyl)phenyl]-2-{[7-(4-methylphenyl)pyrimido[45-d][13]diazin-4-yl]sulfanyl}acetamide

SMILES

Cc(cc1)ccc1-c1ncc2c(SCC(Nc(cc3)c(C(F)(F)F)cc3Cl)=O)ncnc2n1

InChI

InChI=1S/C22H15ClF3N5OS/c1-12-2-4-13(5-3-12)19-27-9-15-20(31-19)28-11-29-21(15)33-10-18(32)30-17-7-6-14(23)8-16(17)22(24,25)26/h2-9,11H,10H2,1H3,(H,30,32)

InChI Key

PDDGNFHQDZWKNO-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27532323

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

489.91

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

5.766

Distribution Coefficient, logD

5.766

Water Solubility, LogSw

-5.96

Polar Surface Area

62.222

Acid Dissociation Constant (pKa)

10.74

Base Dissociation Constant (pKb)

3.51

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

13.60

M143-0765 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Included in 1.7M Stock Database

References: we are preparing a list of scientific research reports with M143-0765 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M143-0765?
Check Price and Availability of M143-0765, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of M143-0765 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M143-0765
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M143-0765
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M143-0765 available by request