M143-0841 Screening compound: N-[(2-bromophenyl)methyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide

M143-0841 Screening compound: N-[(2-bromophenyl)methyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide
M143-0841 Screening compound: N-[(2-bromophenyl)methyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound M143-0841
N-[(2-bromophenyl)methyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M143-0841

Molecular Formula

C22H18BrN5OS (C22 H18 BrN5 OS)

Compound Name

N-[(2-bromophenyl)methyl]-2-{[7-(4-methylphenyl)pyrimido[4,5-d][1,3]diazin-4-yl]sulfanyl}acetamide

IUPAC name

N-[(2-bromophenyl)methyl]-2-{[7-(4-methylphenyl)pyrimido[45-d][13]diazin-4-yl]sulfanyl}acetamide

SMILES

Cc(cc1)ccc1-c1ncc2c(SCC(NCc(cccc3)c3Br)=O)ncnc2n1

InChI

InChI=1S/C22H18BrN5OS/c1-14-6-8-15(9-7-14)20-25-11-17-21(28-20)26-13-27-22(17)30-12-19(29)24-10-16-4-2-3-5-18(16)23/h2-9,11,13H,10,12H2,1H3,(H,24,29)

InChI Key

NCFDGEXSIIQQMF-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27532329

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

480.39

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

5.014

Distribution Coefficient, logD

5.014

Water Solubility, LogSw

-4.56

Polar Surface Area

64.242

Acid Dissociation Constant (pKa)

13.26

Base Dissociation Constant (pKb)

3.51

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

13.60

M143-0841 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

New Agro Library (44492 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases
Agro:
  • Agro

References: we are preparing a list of scientific research reports with M143-0841 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M143-0841?
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What is the minimum amount of M143-0841 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M143-0841
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M143-0841
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M143-0841 available by request