M274-0223 Screening compound: 2,2-dimethyl-1-{3-[2-(3-methylphenyl)-4-pyrimidinyl]piperidino}-1-propanone

M274-0223 Screening compound: 2,2-dimethyl-1-{3-[2-(3-methylphenyl)-4-pyrimidinyl]piperidino}-1-propanone
M274-0223 Screening compound: 2,2-dimethyl-1-{3-[2-(3-methylphenyl)-4-pyrimidinyl]piperidino}-1-propanone alternative view

Chemical Structure Depiction of ChemDiv screening compound M274-0223
2,2-dimethyl-1-{3-[2-(3-methylphenyl)-4-pyrimidinyl]piperidino}-1-propanone

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M274-0223

Molecular Formula

C21H27N3O (C21 H27 N3 O)

Compound Name

2,2-dimethyl-1-{3-[2-(3-methylphenyl)-4-pyrimidinyl]piperidino}-1-propanone

IUPAC name

22-dimethyl-1-{3-[2-(3-methylphenyl)pyrimidin-4-yl]piperidin-1-yl}propan-1-one

SMILES

CC(C)(C)C(N(CCC1)CC1c1nc(-c2cc(C)ccc2)ncc1)=O

InChI

InChI=1S/C21H27N3O/c1-15-7-5-8-16(13-15)19-22-11-10-18(23-19)17-9-6-12-24(14-17)20(25)21(2,3)4/h5,7-8,10-11,13,17H,6,9,12,14H2,1-4H3/t17-/m0/s1

InChI Key

DQDGNIISAAAKRG-KRWDZBQOSA-N

MDL Number (MFCD)

MFCD27534871

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

337.46

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

4.194

Distribution Coefficient, logD

4.194

Water Solubility, LogSw

-4.31

Polar Surface Area

35.552

Acid Dissociation Constant (pKa)

26.34

Base Dissociation Constant (pKb)

4.50

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

47.62

M274-0223 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein-Protein Interaction Library (218420 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
Structure:
  • Cyclic compounds

References: we are preparing a list of scientific research reports with M274-0223 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M274-0223?
Check Price and Availability of M274-0223, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of M274-0223 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M274-0223
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M274-0223
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M274-0223 available by request