M284-0864 Screening compound: N~1~-(4-ethoxybenzyl)-2-[9-methyl-5,11-dioxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]acetamide

Chemical Structure Depiction of ChemDiv screening compound M284-0864
N~1~-(4-ethoxybenzyl)-2-[9-methyl-5,11-dioxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]acetamide

Available from 1 mg

Formats:

Glass Vials (4ml Glass Vials VWR #97047-678)
96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Check Price and Availability

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M284-0864

Molecular Formula

C₂₄H₂₇N₃O₄ (C24 H27 N3 O4)

Compound Name

N~1~-(4-ethoxybenzyl)-2-[9-methyl-5,11-dioxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]acetamide

IUPAC name

N-[(4-ethoxyphenyl)methyl]-2-{11-methyl-28-dioxo-39-diazatricyclo[8.4.0.0^{37}]tetradeca-1(14)1012-trien-9-yl}acetamide

SMILES

CCOc1ccc(CNC(CN(c(c(C)ccc2)c2C(N2C3CCC2)=O)C3=O)=O)cc1

InChI

InChI=1S/C24H27N3O4/c1-3-31-18-11-9-17(10-12-18)14-25-21(28)15-27-22-16(2)6-4-7-19(22)23(29)26-13-5-8-20(26)24(27)30/h4,6-7,9-12,20H,3,5,8,13-15H2,1-2H3,(H,25,28)/t20-/m0/s1

InChI Key

GCTDSENNOWCLEX-FQEVSTJZSA-N

MDL Number (MFCD)

MFCD27535079

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

421.5

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

Partition Coefficient, logP

2.287

Distribution Coefficient, logD

2.287

Water Solubility, LogSw

-2.81

Polar Surface Area

65.025

Acid Dissociation Constant (pK_a)

14.09

Base Dissociation Constant (pK_b)

-2.27

Number of Chiral Centers

1.00

Percent sp³ carbon bonding

37.50

M284-0864 in Drug Discovery

Included in Screening Libraries

Hsp90-Targeted Library (11355 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Protein-Protein Interaction Library (218420 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Epigenetics Focused Set (26518 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Peptidomimetic Library (37031 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Therapeutical areas:

Cancer
Digestive system
Respiratory tract
Male
Female
Hemic and lymphatic
Immune system
Hemic and lymphatic
Cardiovascular
Infections
Cancer
Musculoskeletal
Digestive system
Respiratory tract
Male
Female
Cardiovascular
Skin
Metabolic
Immune system
Cancer

Mechanism of action:

PPI modulators
PPI modulators
PPI modulators
PPI modulators
PPI modulators
PPI modulators

Structure:

Mimetics
Mimetics
Cyclic compounds
Mimetics
Mimetics

Targets:

Proteases

References: we are preparing a list of scientific research reports with M284-0864 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M284-0864?
Check Price and Availability of M284-0864, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.

What is the minimum amount of M284-0864 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.

Delivery options for M284-0864
ChemDiv sends parcels with Express services (UPS, WC).

1–2 days for small orders
2–4 weeks for large selections

Delivery formats for M284-0864

0.5–50 mg of dry powder sample in single glass vials, custom vials
DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M284-0864 available by request