M284-1387 Screening compound: N~1~-(1,3-benzodioxol-5-ylmethyl)-2-[9-methyl-5,11-dioxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]acetamide

M284-1387 Screening compound: N~1~-(1,3-benzodioxol-5-ylmethyl)-2-[9-methyl-5,11-dioxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]acetamide
M284-1387 Screening compound: N~1~-(1,3-benzodioxol-5-ylmethyl)-2-[9-methyl-5,11-dioxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound M284-1387
N~1~-(1,3-benzodioxol-5-ylmethyl)-2-[9-methyl-5,11-dioxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M284-1387

Molecular Formula

C23H23N3O5 (C23 H23 N3 O5)

Compound Name

N~1~-(1,3-benzodioxol-5-ylmethyl)-2-[9-methyl-5,11-dioxo-2,3,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-10(5H)-yl]acetamide

IUPAC name

N-[(2H-13-benzodioxol-5-yl)methyl]-2-{11-methyl-28-dioxo-39-diazatricyclo[8.4.0.0^{37}]tetradeca-1(14)1012-trien-9-yl}acetamide

SMILES

Cc1cccc(C(N2C3CCC2)=O)c1N(CC(NCc(cc1)cc2c1OCO2)=O)C3=O

InChI

InChI=1S/C23H23N3O5/c1-14-4-2-5-16-21(14)26(23(29)17-6-3-9-25(17)22(16)28)12-20(27)24-11-15-7-8-18-19(10-15)31-13-30-18/h2,4-5,7-8,10,17H,3,6,9,11-13H2,1H3,(H,24,27)/t17-/m0/s1

InChI Key

FSUWESAESZYFDC-KRWDZBQOSA-N

MDL Number (MFCD)

MFCD27535128

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

421.45

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

1.831

Distribution Coefficient, logD

1.831

Water Solubility, LogSw

-2.73

Polar Surface Area

75.017

Acid Dissociation Constant (pKa)

14.60

Base Dissociation Constant (pKb)

-0.82

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

34.80

M284-1387 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Antimitotic Tubulin Library (17355 compounds)

Antiviral Library (67538 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Protein-Protein Interaction Library (218420 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Anti-HIV1 Library (19540 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Epigenetics Focused Set (26518 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Peptidomimetic Library (37031 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Antiviral
  • Infections
  • Immune system
  • Hemic and lymphatic
  • Cardiovascular
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
  • Antiviral
  • Infections
  • Immune system
  • Cancer
Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Mimetics
  • Cyclic compounds
  • Mimetics
  • Mimetics
Targets:
  • Proteases

References: we are preparing a list of scientific research reports with M284-1387 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M284-1387?
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What is the minimum amount of M284-1387 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M284-1387
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M284-1387
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M284-1387 available by request