M381-0761 Screening compound: 1-{4-[6-(DIMETHYLAMINO)-4-QUINAZOLINYL]PIPERAZINO}-2-(4-METHOXYPHENYL)-1-ETHANONE

M381-0761 Screening compound: 1-{4-[6-(DIMETHYLAMINO)-4-QUINAZOLINYL]PIPERAZINO}-2-(4-METHOXYPHENYL)-1-ETHANONE
M381-0761 Screening compound: 1-{4-[6-(DIMETHYLAMINO)-4-QUINAZOLINYL]PIPERAZINO}-2-(4-METHOXYPHENYL)-1-ETHANONE alternative view

Chemical Structure Depiction of ChemDiv screening compound M381-0761
1-{4-[6-(DIMETHYLAMINO)-4-QUINAZOLINYL]PIPERAZINO}-2-(4-METHOXYPHENYL)-1-ETHANONE

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M381-0761

Molecular Formula

C23H27N5O2 (C23 H27 N5 O2)

Compound Name

1-{4-[6-(DIMETHYLAMINO)-4-QUINAZOLINYL]PIPERAZINO}-2-(4-METHOXYPHENYL)-1-ETHANONE

IUPAC name

1-{4-[6-(dimethylamino)quinazolin-4-yl]piperazin-1-yl}-2-(4-methoxyphenyl)ethan-1-one

SMILES

CN(C)c(cc12)ccc2ncnc1N(CC1)CCN1C(Cc(cc1)ccc1OC)=O

InChI

InChI=1S/C23H27N5O2/c1-26(2)18-6-9-21-20(15-18)23(25-16-24-21)28-12-10-27(11-13-28)22(29)14-17-4-7-19(30-3)8-5-17/h4-9,15-16H,10-14H2,1-3H3

InChI Key

UDIWAUUQZALMST-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27539798

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

405.5

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.658

Distribution Coefficient, logD

3.410

Water Solubility, LogSw

-4.06

Polar Surface Area

49.426

Acid Dissociation Constant (pKa)

18.21

Base Dissociation Constant (pKb)

7.29

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

34.78

M381-0761 in Drug Discovery

Included in Screening Libraries

GPCR Targeted Library (31838 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • GPCR
  • Kinases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with M381-0761 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M381-0761?
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What is the minimum amount of M381-0761 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M381-0761
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M381-0761
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M381-0761 available by request