M422-0079 Screening compound: 4-amino-N-[(3,5-difluorophenyl)methyl]-3-(pyridin-2-yl)-1,2-thiazole-5-carboxamide

M422-0079 Screening compound: 4-amino-N-[(3,5-difluorophenyl)methyl]-3-(pyridin-2-yl)-1,2-thiazole-5-carboxamide
M422-0079 Screening compound: 4-amino-N-[(3,5-difluorophenyl)methyl]-3-(pyridin-2-yl)-1,2-thiazole-5-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound M422-0079
4-amino-N-[(3,5-difluorophenyl)methyl]-3-(pyridin-2-yl)-1,2-thiazole-5-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M422-0079

Molecular Formula

C16H12F2N4OS (C16 H12 F2 N4 OS)

Compound Name

4-amino-N-[(3,5-difluorophenyl)methyl]-3-(pyridin-2-yl)-1,2-thiazole-5-carboxamide

IUPAC name

4-amino-N-[(35-difluorophenyl)methyl]-3-(pyridin-2-yl)-12-thiazole-5-carboxamide

SMILES

Nc1c(C(NCc2cc(F)cc(F)c2)=O)snc1-c1ncccc1

InChI

InChI=1S/C16H12F2N4OS/c17-10-5-9(6-11(18)7-10)8-21-16(23)15-13(19)14(22-24-15)12-3-1-2-4-20-12/h1-7H,8,19H2,(H,21,23)

InChI Key

KUVZRQUUUDHNCZ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27540815

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

346.36

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

3.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

2.835

Distribution Coefficient, logD

2.835

Water Solubility, LogSw

-3.31

Polar Surface Area

64.076

Acid Dissociation Constant (pKa)

13.20

Base Dissociation Constant (pKb)

4.00

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

6.25

M422-0079 in Drug Discovery

Included in Screening Libraries

Aurora A-B Kinases Targeted Library (9426 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Male
  • Female
  • Hemic and lymphatic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with M422-0079 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M422-0079?
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What is the minimum amount of M422-0079 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M422-0079
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M422-0079
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M422-0079 available by request