M628-0227 Screening compound: 8-[4-(piperidin-1-yl)quinazoline-6-carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane

M628-0227 Screening compound: 8-[4-(piperidin-1-yl)quinazoline-6-carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane
M628-0227 Screening compound: 8-[4-(piperidin-1-yl)quinazoline-6-carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane alternative view

Chemical Structure Depiction of ChemDiv screening compound M628-0227
8-[4-(piperidin-1-yl)quinazoline-6-carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M628-0227

Molecular Formula

C21H26N4O3 (C21 H26 N4 O3)

Compound Name

8-[4-(piperidin-1-yl)quinazoline-6-carbonyl]-1,4-dioxa-8-azaspiro[4.5]decane

IUPAC name

8-[4-(piperidin-1-yl)quinazoline-6-carbonyl]-14-dioxa-8-azaspiro[4.5]decane

SMILES

O=C(c1cc2c(N3CCCCC3)ncnc2cc1)N(CC1)CCC11OCCO1

InChI

InChI=1S/C21H26N4O3/c26-20(25-10-6-21(7-11-25)27-12-13-28-21)16-4-5-18-17(14-16)19(23-15-22-18)24-8-2-1-3-9-24/h4-5,14-15H,1-3,6-13H2

InChI Key

IDPKRRYOCPFRQX-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27549686

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

382.46

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.304

Distribution Coefficient, logD

2.304

Water Solubility, LogSw

-2.67

Polar Surface Area

54.234

Acid Dissociation Constant (pKa)

22.01

Base Dissociation Constant (pKb)

4.33

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

57.14

M628-0227 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Hsp90-Targeted Library (11355 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system

References: we are preparing a list of scientific research reports with M628-0227 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M628-0227?
Check Price and Availability of M628-0227, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of M628-0227 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M628-0227
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M628-0227
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M628-0227 available by request