M976-0277 Screening compound: 4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}-1-(1-propanoyl-2,3-dihydro-1H-indol-5-yl)pyrrolidin-2-one

M976-0277 Screening compound: 4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}-1-(1-propanoyl-2,3-dihydro-1H-indol-5-yl)pyrrolidin-2-one
M976-0277 Screening compound: 4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}-1-(1-propanoyl-2,3-dihydro-1H-indol-5-yl)pyrrolidin-2-one alternative view

Chemical Structure Depiction of ChemDiv screening compound M976-0277
4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}-1-(1-propanoyl-2,3-dihydro-1H-indol-5-yl)pyrrolidin-2-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M976-0277

Molecular Formula

C23H29N3O5 (C23 H29 N3 O5)

Compound Name

4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}-1-(1-propanoyl-2,3-dihydro-1H-indol-5-yl)pyrrolidin-2-one

IUPAC name

4-{14-dioxa-8-azaspiro[4.5]decane-8-carbonyl}-1-(1-propanoyl-23-dihydro-1H-indol-5-yl)pyrrolidin-2-one

SMILES

CCC(N(CC1)c(cc2)c1cc2N(CC(C1)C(N(CC2)CCC22OCCO2)=O)C1=O)=O

InChI

InChI=1S/C23H29N3O5/c1-2-20(27)25-8-5-16-13-18(3-4-19(16)25)26-15-17(14-21(26)28)22(29)24-9-6-23(7-10-24)30-11-12-31-23/h3-4,13,17H,2,5-12,14-15H2,1H3/t17-/m1/s1

InChI Key

UIDDSUAWPVNIPY-QGZVFWFLSA-N

MDL Number (MFCD)

MFCD27558327

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

427.5

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

0.817

Distribution Coefficient, logD

0.817

Water Solubility, LogSw

-1.72

Polar Surface Area

63.496

Acid Dissociation Constant (pKa)

13.27

Base Dissociation Constant (pKb)

3.26

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

60.90

M976-0277 in Drug Discovery

Included in Screening Libraries

Eccentric PPI Library (11937 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Targeted Diversity Library (40567 compounds)

Adenosine Receptors Targeted Library (19896 compounds)

Peptidomimetic Library (37031 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • Receptor's ligands
  • PPI modulators
Structure:
  • Cyclic compounds
  • Mimetics
  • Mimetics
Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Nervous system
  • Eye
  • Cardiovascular
Targets:
  • GPCR

References: we are preparing a list of scientific research reports with M976-0277 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M976-0277?
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What is the minimum amount of M976-0277 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M976-0277
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M976-0277
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M976-0277 available by request