P221-1264 Screening compound: 4-[5-(2,3-DIHYDRO-1H-INDENE-5-SULFONYL)-4H,5H,6H,7H,8H-PYRAZOLO[1,5-A][1,4]DIAZEPIN-2-YL]PYRIDINE

P221-1264 Screening compound: 4-[5-(2,3-DIHYDRO-1H-INDENE-5-SULFONYL)-4H,5H,6H,7H,8H-PYRAZOLO[1,5-A][1,4]DIAZEPIN-2-YL]PYRIDINE
P221-1264 Screening compound: 4-[5-(2,3-DIHYDRO-1H-INDENE-5-SULFONYL)-4H,5H,6H,7H,8H-PYRAZOLO[1,5-A][1,4]DIAZEPIN-2-YL]PYRIDINE alternative view

Chemical Structure Depiction of ChemDiv screening compound P221-1264
4-[5-(2,3-DIHYDRO-1H-INDENE-5-SULFONYL)-4H,5H,6H,7H,8H-PYRAZOLO[1,5-A][1,4]DIAZEPIN-2-YL]PYRIDINE

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

P221-1264

Molecular Formula

C21H22N4O2S (C21 H22 N4 O2 S)

Compound Name

4-[5-(2,3-DIHYDRO-1H-INDENE-5-SULFONYL)-4H,5H,6H,7H,8H-PYRAZOLO[1,5-A][1,4]DIAZEPIN-2-YL]PYRIDINE

IUPAC name

n/a

SMILES

O=S(c1cc(CCC2)c2cc1)(N1Cc2cc(-c3ccncc3)nn2CCC1)=O

InChI

InChI=1S/C21H22N4O2S/c26-28(27,20-6-5-16-3-1-4-18(16)13-20)24-11-2-12-25-19(15-24)14-21(23-25)17-7-9-22-10-8-17/h5-10,13-14H,1-4,11-12,15H2

InChI Key

KOZYSUMINOVOGT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27569729

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

394.5

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.139

Distribution Coefficient, logD

3.138

Water Solubility, LogSw

-3.17

Polar Surface Area

55.195

Acid Dissociation Constant (pKa)

20.77

Base Dissociation Constant (pKb)

4.72

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

33.30

P221-1264 in Drug Discovery

Included in Screening Libraries

Allosteric Kinases Inhibitors Library (23117 compounds)

Antiviral Library (67538 compounds)

PPI Helix Turn 3D-Mimetics Library (71298 compounds)

Protein Arginine Methyltransferases Library (27925 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Alpha-Helix Mimetics Library (25899 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Female
  • Congenital
  • Skin
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Kinases
  • Others
Mechanism of action:
  • PPI modulators
  • Epigenetic
  • PPI modulators
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Mimetics
  • Cyclic compounds
  • Mimetics

References: we are preparing a list of scientific research reports with P221-1264 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound P221-1264?
Check Price and Availability of P221-1264, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of P221-1264 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for P221-1264
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for P221-1264
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of P221-1264 available by request