P223-1095 Screening compound: 2-[1-(2-hydroxy-6-methylpyridine-3-carbonyl)piperidin-3-yl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,4]diazepin-4-one

P223-1095 Screening compound: 2-[1-(2-hydroxy-6-methylpyridine-3-carbonyl)piperidin-3-yl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,4]diazepin-4-one
P223-1095 Screening compound: 2-[1-(2-hydroxy-6-methylpyridine-3-carbonyl)piperidin-3-yl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,4]diazepin-4-one alternative view

Chemical Structure Depiction of ChemDiv screening compound P223-1095
2-[1-(2-hydroxy-6-methylpyridine-3-carbonyl)piperidin-3-yl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,4]diazepin-4-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

P223-1095

Molecular Formula

C19H23N5O3 (C19 H23 N5 O3)

Compound Name

2-[1-(2-hydroxy-6-methylpyridine-3-carbonyl)piperidin-3-yl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,4]diazepin-4-one

IUPAC name

2-[1-(2-hydroxy-6-methylpyridine-3-carbonyl)piperidin-3-yl]-4H5H6H7H8H-pyrazolo[15-a][14]diazepin-4-one

SMILES

Cc(cc1)nc(O)c1C(N(CCC1)CC1c1nn(CCCNC2=O)c2c1)=O

InChI

InChI=1S/C19H23N5O3/c1-12-5-6-14(17(25)21-12)19(27)23-8-2-4-13(11-23)15-10-16-18(26)20-7-3-9-24(16)22-15/h5-6,10,13H,2-4,7-9,11H2,1H3,(H,20,26)(H,21,25)/t13-/m0/s1

InChI Key

DNRQPCLSQSOITO-ZDUSSCGKSA-N

MDL Number (MFCD)

MFCD31952633

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

369.42

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

0.484

Distribution Coefficient, logD

0.474

Water Solubility, LogSw

-2.18

Polar Surface Area

80.728

Acid Dissociation Constant (pKa)

9.04

Base Dissociation Constant (pKb)

1.17

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

47.40

P223-1095 in Drug Discovery

Included in Screening Libraries

PPI Helix Turn 3D-Mimetics Library (71298 compounds)

Protein-Protein Interaction Library (218420 compounds)

Alpha-Helix Mimetics Library (25899 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

MCE-18 Trends in Medicinal Chemistry (51288 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Mimetics
  • Cyclic compounds

References: we are preparing a list of scientific research reports with P223-1095 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound P223-1095?
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What is the minimum amount of P223-1095 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for P223-1095
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for P223-1095
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of P223-1095 available by request