P349-1777 Screening compound: 3-{[2-(4-methylphenyl)imidazo[1,2-a]pyrazin-3-yl]amino}-N-[1-(thiophen-2-yl)ethyl]propanamide

P349-1777 Screening compound: 3-{[2-(4-methylphenyl)imidazo[1,2-a]pyrazin-3-yl]amino}-N-[1-(thiophen-2-yl)ethyl]propanamide
P349-1777 Screening compound: 3-{[2-(4-methylphenyl)imidazo[1,2-a]pyrazin-3-yl]amino}-N-[1-(thiophen-2-yl)ethyl]propanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound P349-1777
3-{[2-(4-methylphenyl)imidazo[1,2-a]pyrazin-3-yl]amino}-N-[1-(thiophen-2-yl)ethyl]propanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

P349-1777

Molecular Formula

C22H23N5OS (C22 H23 N5 OS)

Compound Name

3-{[2-(4-methylphenyl)imidazo[1,2-a]pyrazin-3-yl]amino}-N-[1-(thiophen-2-yl)ethyl]propanamide

IUPAC name

3-{[2-(4-methylphenyl)imidazo[12-a]pyrazin-3-yl]amino}-N-[1-(thiophen-2-yl)ethyl]propanamide

SMILES

CC(c1cccs1)NC(CCNc1c(-c2ccc(C)cc2)nc2n1ccnc2)=O

InChI

InChI=1S/C22H23N5OS/c1-15-5-7-17(8-6-15)21-22(27-12-11-23-14-19(27)26-21)24-10-9-20(28)25-16(2)18-4-3-13-29-18/h3-8,11-14,16,24H,9-10H2,1-2H3,(H,25,28)/t16-/m0/s1

InChI Key

JBDLOCBGYHBYHT-INIZCTEOSA-N

MDL Number (MFCD)

MFCD27573443

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

405.52

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.234

Distribution Coefficient, logD

3.234

Water Solubility, LogSw

-3.34

Polar Surface Area

53.013

Acid Dissociation Constant (pKa)

13.59

Base Dissociation Constant (pKb)

4.18

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

22.70

P349-1777 in Drug Discovery

Included in Screening Libraries

BRD4 Targeted Library (4534 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Hemic and lymphatic
  • Cardiovascular
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with P349-1777 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound P349-1777?
Check Price and Availability of P349-1777, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of P349-1777 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for P349-1777
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for P349-1777
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of P349-1777 available by request