P392-2144 Screening compound: 2-({1-[(4-chloro-2-fluorophenyl)carbamoyl]pyrrolidin-3-yl}oxy)-N,N-dimethylpyridine-3-carboxamide

P392-2144 Screening compound: 2-({1-[(4-chloro-2-fluorophenyl)carbamoyl]pyrrolidin-3-yl}oxy)-N,N-dimethylpyridine-3-carboxamide
P392-2144 Screening compound: 2-({1-[(4-chloro-2-fluorophenyl)carbamoyl]pyrrolidin-3-yl}oxy)-N,N-dimethylpyridine-3-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound P392-2144
2-({1-[(4-chloro-2-fluorophenyl)carbamoyl]pyrrolidin-3-yl}oxy)-N,N-dimethylpyridine-3-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

P392-2144

Molecular Formula

C19H20ClFN4O3 (C19 H20 ClFN4 O3)

Compound Name

2-({1-[(4-chloro-2-fluorophenyl)carbamoyl]pyrrolidin-3-yl}oxy)-N,N-dimethylpyridine-3-carboxamide

IUPAC name

2-({1-[(4-chloro-2-fluorophenyl)carbamoyl]pyrrolidin-3-yl}oxy)-NN-dimethylpyridine-3-carboxamide

SMILES

CN(C)C(c1cccnc1OC(CC1)CN1C(Nc(ccc(Cl)c1)c1F)=O)=O

InChI

InChI=1S/C19H20ClFN4O3/c1-24(2)18(26)14-4-3-8-22-17(14)28-13-7-9-25(11-13)19(27)23-16-6-5-12(20)10-15(16)21/h3-6,8,10,13H,7,9,11H2,1-2H3,(H,23,27)/t13-/m1/s1

InChI Key

QVJGYGSVYGQCIJ-CYBMUJFWSA-N

MDL Number (MFCD)

MFCD28999237

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

406.84

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.362

Distribution Coefficient, logD

2.361

Water Solubility, LogSw

-3.54

Polar Surface Area

57.377

Acid Dissociation Constant (pKa)

10.34

Base Dissociation Constant (pKb)

0.57

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

31.60

P392-2144 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

Bcl2-PPI Inhibitors Library (12246 compounds)

Ligand-Gated Ion Channels Library (3887 compounds)

PPI Helix Turn 3D-Mimetics Library (71298 compounds)

Protein-Protein Interaction Library (218420 compounds)

Alpha-Helix Mimetics Library (25899 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Inhibitors of beta-Catenin Signaling (7445 compounds)

MEF2-HDAC (class II) Modulators Library (5147 compounds)

SH2 PTB Focused Library (6188 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Hemic and lymphatic
  • Nervous system
  • Eye
  • Cancer
  • Musculoskeletal
  • Female
  • Hemic and lymphatic
  • Cardiovascular
Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • Epigenetic
Targets:
  • Ion Channels
Structure:
  • Mimetics
  • Mimetics
  • Cyclic compounds

References: we are preparing a list of scientific research reports with P392-2144 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound P392-2144?
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What is the minimum amount of P392-2144 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for P392-2144
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for P392-2144
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of P392-2144 available by request