P392-2149 Screening compound: 2-({1-[(3,5-difluoroanilino)carbonyl]tetrahydro-1H-pyrrol-3-yl}oxy)-N~3~,N~3~-dimethylnicotinamide

P392-2149 Screening compound: 2-({1-[(3,5-difluoroanilino)carbonyl]tetrahydro-1H-pyrrol-3-yl}oxy)-N~3~,N~3~-dimethylnicotinamide
P392-2149 Screening compound: 2-({1-[(3,5-difluoroanilino)carbonyl]tetrahydro-1H-pyrrol-3-yl}oxy)-N~3~,N~3~-dimethylnicotinamide alternative view

Chemical Structure Depiction of ChemDiv screening compound P392-2149
2-({1-[(3,5-difluoroanilino)carbonyl]tetrahydro-1H-pyrrol-3-yl}oxy)-N~3~,N~3~-dimethylnicotinamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

P392-2149

Molecular Formula

C19H20F2N4O3 (C19 H20 F2 N4 O3)

Compound Name

2-({1-[(3,5-difluoroanilino)carbonyl]tetrahydro-1H-pyrrol-3-yl}oxy)-N~3~,N~3~-dimethylnicotinamide

IUPAC name

2-({1-[(35-difluorophenyl)carbamoyl]pyrrolidin-3-yl}oxy)-NN-dimethylpyridine-3-carboxamide

SMILES

CN(C)C(c1cccnc1OC(CC1)CN1C(Nc1cc(F)cc(F)c1)=O)=O

InChI

InChI=1S/C19H20F2N4O3/c1-24(2)18(26)16-4-3-6-22-17(16)28-15-5-7-25(11-15)19(27)23-14-9-12(20)8-13(21)10-14/h3-4,6,8-10,15H,5,7,11H2,1-2H3,(H,23,27)/t15-/m1/s1

InChI Key

NUMFUNLRFSWYQU-OAHLLOKOSA-N

MDL Number (MFCD)

MFCD28999239

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

390.39

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

1.806

Distribution Coefficient, logD

1.805

Water Solubility, LogSw

-2.43

Polar Surface Area

58.075

Acid Dissociation Constant (pKa)

10.27

Base Dissociation Constant (pKb)

0.57

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

31.58

P392-2149 in Drug Discovery

Included in Screening Libraries

Bcl2-PPI Inhibitors Library (12246 compounds)

Ligand-Gated Ion Channels Library (3887 compounds)

PPI Helix Turn 3D-Mimetics Library (71298 compounds)

Protein-Protein Interaction Library (218420 compounds)

Alpha-Helix Mimetics Library (25899 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Inhibitors of beta-Catenin Signaling (7445 compounds)

MEF2-HDAC (class II) Modulators Library (5147 compounds)

SH2 PTB Focused Library (6188 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Hemic and lymphatic
  • Nervous system
  • Eye
  • Cancer
  • Musculoskeletal
  • Female
  • Hemic and lymphatic
  • Cardiovascular
Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • Epigenetic
Targets:
  • Ion Channels
Structure:
  • Mimetics
  • Mimetics
  • Cyclic compounds

References: we are preparing a list of scientific research reports with P392-2149 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound P392-2149?
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What is the minimum amount of P392-2149 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for P392-2149
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for P392-2149
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of P392-2149 available by request