P682-1457 Screening compound: N-(4-fluoro-3-methylphenyl)-4-hydroxy-1-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

P682-1457 Screening compound: N-(4-fluoro-3-methylphenyl)-4-hydroxy-1-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide
P682-1457 Screening compound: N-(4-fluoro-3-methylphenyl)-4-hydroxy-1-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound P682-1457
N-(4-fluoro-3-methylphenyl)-4-hydroxy-1-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

P682-1457

Molecular Formula

C23H18FN3O4 (C23 H18 FN3 O4)

Compound Name

N-(4-fluoro-3-methylphenyl)-4-hydroxy-1-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

IUPAC name

N-(4-fluoro-3-methylphenyl)-4-hydroxy-1-(3-methoxyphenyl)-2-oxo-12-dihydro-18-naphthyridine-3-carboxamide

SMILES

Cc(cc(cc1)NC(C(C(N(c2cc(OC)ccc2)c2c3cccn2)=O)=C3O)=O)c1F

InChI

InChI=1S/C23H18FN3O4/c1-13-11-14(8-9-18(13)24)26-22(29)19-20(28)17-7-4-10-25-21(17)27(23(19)30)15-5-3-6-16(12-15)31-2/h3-12,28H,1-2H3,(H,26,29)

InChI Key

PQGPGMSFKOZXJR-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27612000

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

419.41

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.238

Distribution Coefficient, logD

-1.386

Water Solubility, LogSw

-3.59

Polar Surface Area

70.767

Acid Dissociation Constant (pKa)

2.78

Base Dissociation Constant (pKb)

-2.49

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

8.70

P682-1457 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

C-Met Library (15277 compounds)

Chelators targeting matrix metalloproteinases library (8930 compounds)

Hsp90-Targeted Library (11355 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
  • Cancer
  • Digestive system
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
Targets:
  • Kinases
  • Proteases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with P682-1457 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound P682-1457?
Check Price and Availability of P682-1457, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of P682-1457 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for P682-1457
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for P682-1457
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of P682-1457 available by request