P764-0272 Screening compound: 8-{1-[2-(piperidin-1-yl)ethyl]-1H-indazole-3-carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane

P764-0272 Screening compound: 8-{1-[2-(piperidin-1-yl)ethyl]-1H-indazole-3-carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane
P764-0272 Screening compound: 8-{1-[2-(piperidin-1-yl)ethyl]-1H-indazole-3-carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane alternative view

Chemical Structure Depiction of ChemDiv screening compound P764-0272
8-{1-[2-(piperidin-1-yl)ethyl]-1H-indazole-3-carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

P764-0272

Molecular Formula

C22H30N4O3 (C22 H30 N4 O3)

Compound Name

8-{1-[2-(piperidin-1-yl)ethyl]-1H-indazole-3-carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane

IUPAC name

8-{1-[2-(piperidin-1-yl)ethyl]-1H-indazole-3-carbonyl}-14-dioxa-8-azaspiro[4.5]decane

SMILES

O=C(c1nn(CCN2CCCCC2)c2c1cccc2)N(CC1)CCC11OCCO1

InChI

InChI=1S/C22H30N4O3/c27-21(25-12-8-22(9-13-25)28-16-17-29-22)20-18-6-2-3-7-19(18)26(23-20)15-14-24-10-4-1-5-11-24/h2-3,6-7H,1,4-5,8-17H2

InChI Key

OFIKQTONPJNDDS-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27614501

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

398.51

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

1.691

Distribution Coefficient, logD

1.016

Water Solubility, LogSw

-1.95

Polar Surface Area

49.263

Acid Dissociation Constant (pKa)

27.37

Base Dissociation Constant (pKb)

7.97

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

63.60

P764-0272 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CNS BBB Library (22607 compounds)

GPCR Targeted Library (31838 compounds)

SmartTM Library (51161 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
Targets:
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with P764-0272 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound P764-0272?
Check Price and Availability of P764-0272, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of P764-0272 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for P764-0272
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for P764-0272
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of P764-0272 available by request