S372-1477 Screening compound: N-(2-methoxyethyl)-4-({1-oxo-1H,2H,7H,8H,9H,10H-pyrazino[1,2-b]indazol-2-yl}methyl)benzamide

S372-1477 Screening compound: N-(2-methoxyethyl)-4-({1-oxo-1H,2H,7H,8H,9H,10H-pyrazino[1,2-b]indazol-2-yl}methyl)benzamide
S372-1477 Screening compound: N-(2-methoxyethyl)-4-({1-oxo-1H,2H,7H,8H,9H,10H-pyrazino[1,2-b]indazol-2-yl}methyl)benzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound S372-1477
N-(2-methoxyethyl)-4-({1-oxo-1H,2H,7H,8H,9H,10H-pyrazino[1,2-b]indazol-2-yl}methyl)benzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

S372-1477

Molecular Formula

C21H24N4O3 (C21 H24 N4 O3)

Compound Name

N-(2-methoxyethyl)-4-({1-oxo-1H,2H,7H,8H,9H,10H-pyrazino[1,2-b]indazol-2-yl}methyl)benzamide

IUPAC name

N-(2-methoxyethyl)-4-({1-oxo-1H2H7H8H9H10H-pyrazino[12-b]indazol-2-yl}methyl)benzamide

SMILES

COCCNC(c1ccc(CN(C=Cn2nc(CCCC3)c3c22)C2=O)cc1)=O

InChI

InChI=1S/C21H24N4O3/c1-28-13-10-22-20(26)16-8-6-15(7-9-16)14-24-11-12-25-19(21(24)27)17-4-2-3-5-18(17)23-25/h6-9,11-12H,2-5,10,13-14H2,1H3,(H,22,26)

InChI Key

GTMOQLOUOSINBE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD29001754

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

380.45

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

0.832

Distribution Coefficient, logD

0.832

Water Solubility, LogSw

-1.95

Polar Surface Area

62.308

Acid Dissociation Constant (pKa)

13.05

Base Dissociation Constant (pKb)

1.50

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

38.10

S372-1477 in Drug Discovery

Included in Screening Libraries

Angiogenesis library (14822 compounds)

Protein-Protein Interaction Library (218420 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds

References: we are preparing a list of scientific research reports with S372-1477 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound S372-1477?
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What is the minimum amount of S372-1477 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for S372-1477
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for S372-1477
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of S372-1477 available by request