S373-1261 Screening compound: 4-(4-{7H,8H,9H,10H-pyrazino[1,2-b]indazol-1-yl}piperazine-1-carbonyl)-1H-indole

S373-1261 Screening compound: 4-(4-{7H,8H,9H,10H-pyrazino[1,2-b]indazol-1-yl}piperazine-1-carbonyl)-1H-indole
S373-1261 Screening compound: 4-(4-{7H,8H,9H,10H-pyrazino[1,2-b]indazol-1-yl}piperazine-1-carbonyl)-1H-indole alternative view

Chemical Structure Depiction of ChemDiv screening compound S373-1261
4-(4-{7H,8H,9H,10H-pyrazino[1,2-b]indazol-1-yl}piperazine-1-carbonyl)-1H-indole

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

S373-1261

Molecular Formula

C23H24N6O (C23 H24 N6 O)

Compound Name

4-(4-{7H,8H,9H,10H-pyrazino[1,2-b]indazol-1-yl}piperazine-1-carbonyl)-1H-indole

IUPAC name

4-(4-{7H8H9H10H-pyrazino[12-b]indazol-1-yl}piperazine-1-carbonyl)-1H-indole

SMILES

O=C(c1c(cc[nH]2)c2ccc1)N(CC1)CCN1c1nccn2nc(CCCC3)c3c12

InChI

InChI=1S/C23H24N6O/c30-23(17-5-3-7-19-16(17)8-9-24-19)28-14-12-27(13-15-28)22-21-18-4-1-2-6-20(18)26-29(21)11-10-25-22/h3,5,7-11,24H,1-2,4,6,12-15H2

InChI Key

GQPPXNJEGGTKRS-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD29001763

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

400.48

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.007

Distribution Coefficient, logD

2.006

Water Solubility, LogSw

-2.61

Polar Surface Area

50.913

Acid Dissociation Constant (pKa)

17.81

Base Dissociation Constant (pKb)

4.46

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

34.80

S373-1261 in Drug Discovery

Included in Screening Libraries

3D-Diversity Natural-Product-Like Library (18102 compounds)

Bcl2-PPI Inhibitors Library (12246 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Indole Derivatives (10091 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Structure:
  • 3D
  • Cyclic compounds
  • Mimetics
Therapeutical areas:
  • Cancer
  • Hemic and lymphatic
  • Cancer
Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators

References: we are preparing a list of scientific research reports with S373-1261 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound S373-1261?
Check Price and Availability of S373-1261, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of S373-1261 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for S373-1261
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for S373-1261
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of S373-1261 available by request