S380-0262 Screening compound: N-(3-fluoro-4-methylphenyl)-2-{8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl}acetamide

S380-0262 Screening compound: N-(3-fluoro-4-methylphenyl)-2-{8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl}acetamide
S380-0262 Screening compound: N-(3-fluoro-4-methylphenyl)-2-{8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl}acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound S380-0262
N-(3-fluoro-4-methylphenyl)-2-{8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl}acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

S380-0262

Molecular Formula

C18H22FN3O3 (C18 H22 FN3 O3)

Compound Name

N-(3-fluoro-4-methylphenyl)-2-{8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl}acetamide

IUPAC name

N-(3-fluoro-4-methylphenyl)-2-{8-methyl-24-dioxo-13-diazaspiro[4.5]decan-3-yl}acetamide

SMILES

CC(CC1)CCC1(C(N1CC(Nc2cc(F)c(C)cc2)=O)=O)NC1=O

InChI

InChI=1S/C18H22FN3O3/c1-11-5-7-18(8-6-11)16(24)22(17(25)21-18)10-15(23)20-13-4-3-12(2)14(19)9-13/h3-4,9,11H,5-8,10H2,1-2H3,(H,20,23)(H,21,25)

InChI Key

MFDSILDQVCNWBM-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD03986369

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

347.39

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.347

Distribution Coefficient, logD

3.347

Water Solubility, LogSw

-3.44

Polar Surface Area

64.987

Acid Dissociation Constant (pKa)

10.84

Base Dissociation Constant (pKb)

1.71

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

50.00

S380-0262 in Drug Discovery

Included in Screening Libraries

Protein-Protein Interaction Library (218420 compounds)

SH2 Library (10483 compounds)

Spiro Library (21655 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
Therapeutical areas:
  • Cancer
  • Endocrine
  • Cancer
Structure:
  • Cyclic compounds
  • Cyclic compounds

References: we are preparing a list of scientific research reports with S380-0262 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound S380-0262?
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What is the minimum amount of S380-0262 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for S380-0262
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for S380-0262
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of S380-0262 available by request