T387-0746 Screening compound: 1-{1-[5-(4-fluorophenyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]piperidine-4-carbonyl}-4-methylpiperazine

T387-0746 Screening compound: 1-{1-[5-(4-fluorophenyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]piperidine-4-carbonyl}-4-methylpiperazine
T387-0746 Screening compound: 1-{1-[5-(4-fluorophenyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]piperidine-4-carbonyl}-4-methylpiperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound T387-0746
1-{1-[5-(4-fluorophenyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]piperidine-4-carbonyl}-4-methylpiperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

T387-0746

Molecular Formula

C23H26FN5OS (C23 H26 FN5 OS)

Compound Name

1-{1-[5-(4-fluorophenyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]piperidine-4-carbonyl}-4-methylpiperazine

IUPAC name

1-{1-[5-(4-fluorophenyl)-[13]thiazolo[54-b]pyridin-2-yl]piperidine-4-carbonyl}-4-methylpiperazine

SMILES

CN(CC1)CCN1C(C(CC1)CCN1c1nc2ccc(-c(cc3)ccc3F)nc2s1)=O

InChI

InChI=1S/C23H26FN5OS/c1-27-12-14-28(15-13-27)22(30)17-8-10-29(11-9-17)23-26-20-7-6-19(25-21(20)31-23)16-2-4-18(24)5-3-16/h2-7,17H,8-15H2,1H3

InChI Key

ZKUPKHFDRZHVBR-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27619115

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

439.56

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.957

Distribution Coefficient, logD

3.609

Water Solubility, LogSw

-3.98

Polar Surface Area

42.053

Acid Dissociation Constant (pKa)

20.97

Base Dissociation Constant (pKb)

7.49

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

43.50

T387-0746 in Drug Discovery

Included in Screening Libraries

Antiviral Library (67538 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Antiviral
  • Infections
  • Immune system
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Cyclic compounds
Targets:
  • Phosphatases

References: we are preparing a list of scientific research reports with T387-0746 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound T387-0746?
Check Price and Availability of T387-0746, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of T387-0746 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for T387-0746
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for T387-0746
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of T387-0746 available by request