T604-0327 Screening compound: 3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-2-(4-fluorophenyl)-5-(2-hydroxyethyl)-6-methyl-3,4-dihydropyrimidin-4-one

T604-0327 Screening compound: 3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-2-(4-fluorophenyl)-5-(2-hydroxyethyl)-6-methyl-3,4-dihydropyrimidin-4-one
T604-0327 Screening compound: 3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-2-(4-fluorophenyl)-5-(2-hydroxyethyl)-6-methyl-3,4-dihydropyrimidin-4-one alternative view

Chemical Structure Depiction of ChemDiv screening compound T604-0327
3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-2-(4-fluorophenyl)-5-(2-hydroxyethyl)-6-methyl-3,4-dihydropyrimidin-4-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

T604-0327

Molecular Formula

C24H21ClFN3O3 (C24 H21 ClFN3 O3)

Compound Name

3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-2-(4-fluorophenyl)-5-(2-hydroxyethyl)-6-methyl-3,4-dihydropyrimidin-4-one

IUPAC name

3-{[2-(4-chlorophenyl)-5-methyl-13-oxazol-4-yl]methyl}-2-(4-fluorophenyl)-5-(2-hydroxyethyl)-6-methyl-34-dihydropyrimidin-4-one

SMILES

Cc1c(CN(C(c(cc2)ccc2F)=NC(C)=C2CCO)C2=O)nc(-c(cc2)ccc2Cl)o1

InChI

InChI=1S/C24H21ClFN3O3/c1-14-20(11-12-30)24(31)29(22(27-14)16-5-9-19(26)10-6-16)13-21-15(2)32-23(28-21)17-3-7-18(25)8-4-17/h3-10,30H,11-13H2,1-2H3

InChI Key

PMLKTAAKIDNUAE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD28997957

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

453.9

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.686

Distribution Coefficient, logD

3.685

Water Solubility, LogSw

-4.22

Polar Surface Area

59.779

Acid Dissociation Constant (pKa)

15.18

Base Dissociation Constant (pKb)

4.32

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

20.80

T604-0327 in Drug Discovery

Included in Screening Libraries

Antifungal Library (16415 compounds)

Bcl2-PPI Inhibitors Library (12246 compounds)

Bromodomain Modulators Library (5801 compounds)

Inhibitors of beta-Catenin Signaling (7445 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Infections
  • Immune system
  • animal
  • Cancer
  • Hemic and lymphatic
Agro:
  • Agro
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with T604-0327 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound T604-0327?
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What is the minimum amount of T604-0327 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for T604-0327
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for T604-0327
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of T604-0327 available by request