V018-4588 Screening compound: 1-[(2,4-difluorophenyl)methyl]-N-(3-methylphenyl)-2-oxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-3'-carboxamide

V018-4588 Screening compound: 1-[(2,4-difluorophenyl)methyl]-N-(3-methylphenyl)-2-oxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-3'-carboxamide
V018-4588 Screening compound: 1-[(2,4-difluorophenyl)methyl]-N-(3-methylphenyl)-2-oxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-3'-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound V018-4588
1-[(2,4-difluorophenyl)methyl]-N-(3-methylphenyl)-2-oxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-3'-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

V018-4588

Molecular Formula

C25H21F2N3O2S (C25 H21 F2 N3 O2 S)

Compound Name

1-[(2,4-difluorophenyl)methyl]-N-(3-methylphenyl)-2-oxo-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-3'-carboxamide

IUPAC name

1-[(24-difluorophenyl)methyl]-N-(3-methylphenyl)-2-oxo-12-dihydrospiro[indole-32'-[13]thiazolidine]-3'-carboxamide

SMILES

Cc1cccc(NC(N2C(c(cccc3)c3N3Cc(ccc(F)c4)c4F)(C3=O)SCC2)=O)c1

InChI

InChI=1S/C25H21F2N3O2S/c1-16-5-4-6-19(13-16)28-24(32)30-11-12-33-25(30)20-7-2-3-8-22(20)29(23(25)31)15-17-9-10-18(26)14-21(17)27/h2-10,13-14H,11-12,15H2,1H3,(H,28,32)/t25-/m0/s1

InChI Key

ISCGZDIHUTUDFK-VWLOTQADSA-N

MDL Number (MFCD)

MFCD19871684

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

465.52

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.333

Distribution Coefficient, logD

5.333

Water Solubility, LogSw

-5.29

Polar Surface Area

40.400

Acid Dissociation Constant (pKa)

14.69

Base Dissociation Constant (pKb)

-0.91

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

20.00

V018-4588 in Drug Discovery

Included in Screening Libraries

Protein Arginine Methyltransferases Library (27925 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with V018-4588 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound V018-4588?
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What is the minimum amount of V018-4588 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for V018-4588
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for V018-4588
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of V018-4588 available by request