V022-1457 Screening compound: 5-chloro-3'-(4-methoxybenzoyl)-5',5'-dimethyl-1-[(2-methylphenyl)methyl]-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidin]-2-one

V022-1457 Screening compound: 5-chloro-3'-(4-methoxybenzoyl)-5',5'-dimethyl-1-[(2-methylphenyl)methyl]-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidin]-2-one
V022-1457 Screening compound: 5-chloro-3'-(4-methoxybenzoyl)-5',5'-dimethyl-1-[(2-methylphenyl)methyl]-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidin]-2-one alternative view

Chemical Structure Depiction of ChemDiv screening compound V022-1457
5-chloro-3'-(4-methoxybenzoyl)-5',5'-dimethyl-1-[(2-methylphenyl)methyl]-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidin]-2-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

V022-1457

Molecular Formula

C28H27ClN2O3S (C28 H27 ClN2 O3 S)

Compound Name

5-chloro-3'-(4-methoxybenzoyl)-5',5'-dimethyl-1-[(2-methylphenyl)methyl]-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidin]-2-one

IUPAC name

5-chloro-3'-(4-methoxybenzoyl)-5'5'-dimethyl-1-[(2-methylphenyl)methyl]-12-dihydrospiro[indole-32'-[13]thiazolidin]-2-one

SMILES

CC(C)(C1)SC(c(cc(cc2)Cl)c2N2Cc3c(C)cccc3)(C2=O)N1C(c(cc1)ccc1OC)=O

InChI

InChI=1S/C28H27ClN2O3S/c1-18-7-5-6-8-20(18)16-30-24-14-11-21(29)15-23(24)28(26(30)33)31(17-27(2,3)35-28)25(32)19-9-12-22(34-4)13-10-19/h5-15H,16-17H2,1-4H3/t28-/m0/s1

InChI Key

ZRMKSPMKOJKYIO-NDEPHWFRSA-N

MDL Number (MFCD)

MFCD19870629

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

507.05

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

6.897

Distribution Coefficient, logD

6.897

Water Solubility, LogSw

-6.14

Polar Surface Area

39.057

Acid Dissociation Constant (pKa)

26.78

Base Dissociation Constant (pKb)

-4.75

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

28.60

V022-1457 in Drug Discovery

Included in Screening Libraries

Antiviral Library (67538 compounds)

Glucocorticoid receptors Library (4806 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Nervous system
  • Hemic and lymphatic
  • Congenital
  • Metabolic
  • Endocrine
Targets:
  • Nuclear receptors
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with V022-1457 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound V022-1457?
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What is the minimum amount of V022-1457 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for V022-1457
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for V022-1457
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of V022-1457 available by request