Z218-4449 Screening compound: N1-[3-(1-ETHYL-6-METHOXY-1H-INDOL-2-YL)-1H-PYRAZOL-5-YL]-2-(2-THIENYL)ACETAMIDE

Z218-4449 Screening compound: N1-[3-(1-ETHYL-6-METHOXY-1H-INDOL-2-YL)-1H-PYRAZOL-5-YL]-2-(2-THIENYL)ACETAMIDE
Z218-4449 Screening compound: N1-[3-(1-ETHYL-6-METHOXY-1H-INDOL-2-YL)-1H-PYRAZOL-5-YL]-2-(2-THIENYL)ACETAMIDE alternative view

Chemical Structure Depiction of ChemDiv screening compound Z218-4449
N1-[3-(1-ETHYL-6-METHOXY-1H-INDOL-2-YL)-1H-PYRAZOL-5-YL]-2-(2-THIENYL)ACETAMIDE

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

Z218-4449

Molecular Formula

C20H20N4O2S (C20 H20 N4 O2 S)

Compound Name

N1-[3-(1-ETHYL-6-METHOXY-1H-INDOL-2-YL)-1H-PYRAZOL-5-YL]-2-(2-THIENYL)ACETAMIDE

IUPAC name

n/a

SMILES

CCn(c(-c1n[nH]c(NC(Cc2cccs2)=O)c1)c1)c2c1ccc(OC)c2

InChI

InChI=1S/C20H20N4O2S/c1-3-24-17-10-14(26-2)7-6-13(17)9-18(24)16-12-19(23-22-16)21-20(25)11-15-5-4-8-27-15/h4-10,12H,3,11H2,1-2H3,(H2,21,22,23,25)

InChI Key

KFOJLZBDSDFCSZ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27635390

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

380.47

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.594

Distribution Coefficient, logD

3.594

Water Solubility, LogSw

-3.77

Polar Surface Area

55.186

Acid Dissociation Constant (pKa)

13.23

Base Dissociation Constant (pKb)

0.17

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

20.00

Z218-4449 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

C-Met Library (15277 compounds)

Indole Derivatives (10091 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
Targets:
  • Kinases
Mechanism of action:
  • Receptor's ligands
Structure:
  • Cyclic compounds

References: we are preparing a list of scientific research reports with Z218-4449 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound Z218-4449?
Check Price and Availability of Z218-4449, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of Z218-4449 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for Z218-4449
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for Z218-4449
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of Z218-4449 available by request