Z218-4459 Screening compound: N-[3-(1-ethyl-6-methoxy-1H-indol-2-yl)-1H-pyrazol-5-yl]cyclopentanecarboxamide

Z218-4459 Screening compound: N-[3-(1-ethyl-6-methoxy-1H-indol-2-yl)-1H-pyrazol-5-yl]cyclopentanecarboxamide
Z218-4459 Screening compound: N-[3-(1-ethyl-6-methoxy-1H-indol-2-yl)-1H-pyrazol-5-yl]cyclopentanecarboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound Z218-4459
N-[3-(1-ethyl-6-methoxy-1H-indol-2-yl)-1H-pyrazol-5-yl]cyclopentanecarboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

Z218-4459

Molecular Formula

C20H24N4O2 (C20 H24 N4 O2)

Compound Name

N-[3-(1-ethyl-6-methoxy-1H-indol-2-yl)-1H-pyrazol-5-yl]cyclopentanecarboxamide

IUPAC name

N-[3-(1-ethyl-6-methoxy-1H-indol-2-yl)-1H-pyrazol-5-yl]cyclopentanecarboxamide

SMILES

CCn(c(-c1n[nH]c(NC(C2CCCC2)=O)c1)c1)c2c1ccc(OC)c2

InChI

InChI=1S/C20H24N4O2/c1-3-24-17-11-15(26-2)9-8-14(17)10-18(24)16-12-19(23-22-16)21-20(25)13-6-4-5-7-13/h8-13H,3-7H2,1-2H3,(H2,21,22,23,25)

InChI Key

HBNNTOFKQWNWCF-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27635396

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

352.44

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.085

Distribution Coefficient, logD

4.085

Water Solubility, LogSw

-4.26

Polar Surface Area

54.939

Acid Dissociation Constant (pKa)

12.87

Base Dissociation Constant (pKb)

-0.40

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

40.00

Z218-4459 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

C-Met Library (15277 compounds)

Indole Derivatives (10091 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Targets:
  • Kinases
  • Phosphatases
Mechanism of action:
  • Receptor's ligands
Structure:
  • Cyclic compounds

References: we are preparing a list of scientific research reports with Z218-4459 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound Z218-4459?
Check Price and Availability of Z218-4459, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of Z218-4459 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for Z218-4459
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for Z218-4459
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of Z218-4459 available by request